Open AccessDiscovery of novel human epidermal growth factor Receptor-2 inhibitors by structure-based virtual screening
Author(s) -
Zheng Shi,
Tian Yu,
Rong Sun,
Shan Wang,
Xiaoqian Chen,
Cheng Liu,
Rong Liu
Publication year - 2016
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.177912
Subject(s) - virtual screening , christian ministry , cancer , medicine , breast cancer , epidermal growth factor receptor , human epidermal growth factor receptor 2 , traditional chinese medicine , drug discovery , pharmacology , traditional medicine , oncology , bioinformatics , biology , alternative medicine , pathology , political science , law
Human epidermal growth factor receptor-2 (HER2) is a trans-membrane receptor like protein, and aberrant signaling of HER2 is implicated in many human cancers, such as ovarian cancer, gastric cancer, and prostate cancer, most notably breast cancer. Moreover, it has been in the spotlight in the recent years as a promising new target for therapy of breast cancer.