Open AccessPhenolic alkaloids from Menispermum dauricum inhibits BxPC-3 pancreatic cancer cells by blocking of Hedgehog signaling pathway
Author(s) -
Zhong-Guang Zhou,
Chaoying Zhang,
Fei Hong-xin,
Lili Zhong,
Yun Bai
Publication year - 2015
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.165548
Subject(s) - apoptosis , cell cycle , cancer research , cell growth , pancreatic cancer , cell cycle checkpoint , chemistry , hedgehog , cell , signal transduction , biology , cancer , microbiology and biotechnology , medicine , biochemistry
The Hedgehog (Hh) signaling pathway plays an important role in pancreatic cancer (PC) cells. Phenolic alkaloids from Menispermum dauricum (PAMD), a traditional Chinese medicine used for the treatment of immune disorders, have been reported to have antitumor activity recently.