Open AccessTwo new cyclopeptides from the co-culture broth of two marine mangrove fungi and their antifungal activity
Author(s) -
Song Huang,
Weijia Ding,
Chunyuan Li,
Daniel G. Cox
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.141781
Subject(s) - candida albicans , antifungal , alternaria , marine fungi , chemistry , fusarium , mangrove , stereochemistry , microbiology and biotechnology , biology , botany , ecology
The strategy that co-cultivation two microorganisms in a single confined environment were recently developed to generate new active natural products. In the study, two new cyclic tetrapeptides, cyclo (D-Pro-L-Tyr-L-Pro-L-Tyr) (1) and cyclo (Gly-L-Phe-L-Pro-L-Tyr) (2) were isolated from the co-culture broth of two mangrove fungi Phomopsis sp. K38 and Alternaria sp. E33. Their antifungal activity against Candida albicans, Gaeumannomyces graminis, Rhzioctonia cerealis, Helminthosporium sativum and Fusarium graminearum was evaluated.