Open AccessIdentification of natural inhibitors against angiotensin I converting enzyme for cardiac safety using induced fit docking and MM-GBSA studies
Author(s) -
Vijayakumar Balakrishnan,
Subramani Parasuraman,
R Raveendran,
D. Velmurugan
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.139809
Subject(s) - docking (animal) , adme , chemistry , in silico , captopril , angiotensin converting enzyme , stereochemistry , active site , pharmacology , enzyme , biochemistry , medicine , nursing , blood pressure , in vitro , gene
Cleistanthins A and B are isolated compounds from the leaves of Cleistanthus collinus Roxb (Euphorbiaceae). This plant is poisonous in nature which causes cardiovascular abnormalities such as hypotension, nonspecific ST-T changes and QTc prolongation. The biological activity predictions spectra of the compounds show the presence of antihypertensive, diuretic and antitumor activities.