Open AccessAntidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression
Author(s) -
Yunhui Li,
Chunhu Zhang,
Juan Qiu,
Sue Wang,
HansUllrich Spiegel,
Xi Huang,
Ying Xie,
Yang Wang,
Tianli Cheng
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.137367
Subject(s) - antidepressant , hippocampus , fluoxetine , open field , behavioural despair test , pharmacology , signal transduction , western blot , medicine , apoptosis , depression (economics) , kinase , chemistry , biochemistry , receptor , serotonin , gene , macroeconomics , economics
Chaihu-Shugan-San (CHSGS), a traditional Chinese medicinal herbal formula, registered in Jingyue Quanshu, has been indicated that oral administration of the extract from it can remit depressive disorder. C-Jun amino-terminal kinase (JNK/SAPK) signal transduction plays a key role in the apoptosis of nerve cells, be reported closely correlated with depression. This study was designed to investigate CHSGS antidepressant-like effects in rat models of depression and probe its possible mechanism.