Open AccessNew Sesquiterpene and Polymethoxy-Flavonoids from Artemisia annua L
Author(s) -
Yang Chu,
Hongbo Wang,
Jing Chen,
Yue Hou
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.137359
Subject(s) - artemisia annua , artemisinin , phytochemical , sesquiterpene , traditional medicine , chemistry , cancer cell lines , biology , plasmodium falciparum , malaria , stereochemistry , cancer , medicine , cancer cell , immunology , genetics
Our previous study revealed that the polymethoxy-flavonoids, as main components of Artemisia annua, could improve the antimalarial activity of Artemisinin. Here, we described the isolation, elucidation, constituent analysis, flavonoids enrichment of the extracts of A. annua. A total of 20 compounds were isolated including a new sesquiterpene (compound 12) and five (1, 5, 6, 7, 15) afforded for the first time from A. annua. The elucidation of eight flavonoids may be a useful phytochemical data and chemical foundation for further mechanism studies on improving the anti-malarial action of artemisinin. Furthermore, the antitumor activities of the compounds were assayed using four different kinds of human cancer cell lines.