Open AccessEvaluation of the hypolipidemic activity of 6,7-dimethoxycoumarin on placental tissue factor mRNA expression in experimental anti-phospholipid syndrome
Author(s) -
Annamalai Amarnath,
Veeraval Lenin,
Govindaraju Archunan
Publication year - 2013
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.113287
Subject(s) - tissue factor , placenta , phospholipid , endocrinology , medicine , fetus , gestation , biology , cholesterol , andrology , pregnancy , biochemistry , genetics , membrane , coagulation
Anti-phospholipid syndrome is a thrombogenic and systemic autoimmune disorder that influences fetal life throughout gestation period. Over expression of tissue factor on the surface of monocyte(s) is reported to be a major causative agent in inducing anti-phospholipid antibody-mediated placental thrombosis and fetal loss in pregnant women. The over expression of tissue factor is proposed to be due to high levels of blood cholesterol and oxidized lipoproteins.