Open AccessPregabalin in chemotherapy induced neuropathic pain
Author(s) -
Shrikant Atreya
Publication year - 2016
Publication title -
indian journal of palliative care/indian journal of palliative care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 26
eISSN - 1998-3735
pISSN - 0973-1075
DOI - 10.4103/0973-1075.173941
Subject(s) - pregabalin , medicine , neuropathic pain , allodynia , peripheral neuropathy , vinca , anesthesia , chemotherapy , gabapentin , hyperalgesia , chemotherapy induced peripheral neuropathy , pharmacology , nociception , receptor , endocrinology , alternative medicine , pathology , diabetes mellitus
Chemotherapeutic agents belonging to vinca alkaloids, taxanes, and antitubulins produce peripheral neuropathy for which there is no validated treatment. Pregabalin, a gamma-aminobutyric acid analog, is known to inhibit theα2δ subunit of the voltage-gated calcium channel. Earlier studies and case reports have shown pregabalin to be effective in treating neuropathic pain. We present a case series of patients with chemotherapy-induced peripheral neuropathy who were successfully treated with pregabalin with reduction in the hyperalgesia, allodynia, and improvement in the quality of life.