Open Accessα4β1 integrin-dependent cell sorting dictates T-cell recruitment in oral submucous fibrosis
Author(s) -
R. Rajendran,
Kuppili Deepthi,
Nasser Nooh,
Sukumaran Anil
Publication year - 2011
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.86678
Subject(s) - integrin , interquartile range , homing (biology) , lymphocyte , lymphocyte homing receptor , medicine , pathology , immunology , andrology , microbiology and biotechnology , biology , cell adhesion , cell , receptor , ecology , genetics
The biological mechanism(s) that guide the immunological effectors of lymphocytes to sites of inflammatory response, a feature consistently seen in oral submucous fibrosis (OSF) was evaluated. It is envisaged that endothelial/lymphocyte adhesion cascades involving VCAM-1/α4β1 integrins control the migration of lymphocytes across the vascular endothelium resulting in their homing in these locales.