Open AccessOral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
Author(s) -
S Balasundaram,
K Ranganathan,
K. M. R. Umadevi,
Gunaseelan Rajan,
Nagarathna Hosalli Kumaraswamy,
Sunithi Solomon,
Bella Devaleenol,
Amrose Pradeep
Publication year - 2011
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.80024
Subject(s) - nevirapine , medicine , dermatology , reverse transcriptase inhibitor , nucleoside reverse transcriptase inhibitor , human immunodeficiency virus (hiv) , reverse transcriptase , hypersensitivity reaction , virology , antiretroviral therapy , gastroenterology , immunology , viral load , biology , rna , biochemistry , gene
Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.