Open AccessImmunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium
Author(s) -
Thara Aravind,
Mahija Janardhanan,
S Rakesh,
Vindhya Savithri,
U G Unnikrishnan
Publication year - 2017
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.203764
Subject(s) - osteopontin , epithelium , pathology , basal cell , cancer research , cell , biology , medicine , genetics
Early detection of oral squamous cell carcinoma (OSCC) remains one of the most efficient ways to ensure patient survival and improved quality of life. Although specific biomarkers related to OSCC have been investigated, a useful biomarker that assesses the transition potential of potentially malignant lesion to OSCC remains to be found. Osteopontin (OPN) has been recognized as an important factor in tumorigenesis and their expression in OSCC have been investigated earlier. In the present study, evaluation of OPN expression in premalignant and malignant lesions has been carried out to assess their possible role as a biomarker in the early diagnosis and prognosis of OSCC.