Open AccessThe synergy of tobacco and alcohol and glutathione S-transferase θ 1 gene deletion and oral squamous cell carcinoma
Author(s) -
Sarah D' Mello,
Radhika M Bavle,
K Paremala,
Soumya Makarla,
M Sudhakara,
Madhura Bhatt
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.190898
Subject(s) - genotype , buccal swab , biology , glutathione s transferase , gene , locus (genetics) , gene polymorphism , polymerase chain reaction , basal cell , cancer research , genetics , microbiology and biotechnology , glutathione , pathology , enzyme , medicine , biochemistry
Oral squamous cell carcinoma (OSCC) is the leading cancer among males in India. It is related to tobacco habits and alcohol consumption as well as the individual susceptibility for xenobiotic metabolizing enzyme polymorphisms. Glutathione S-transferase θ 1 (GSTT1) is a Phase II metabolic enzyme which is directly involved in catalyzing chemicals to mutagenic intermediates. This gene is characterized by genetic polymorphism resulting in complete gene deletion and subsequent absence of the enzyme, which ultimately dictates the risk of cancer development. Scraping buccal mucosa to obtain DNA from the cells is a simple, readily acceptable and rapid method to detect and assess the gene.