Open AccessKallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors
Author(s) -
Marcelo Macedo Crivelini,
Denise Tostes Oliveira,
Ricardo Alves Mesquita,
Suzana Cantanhede Orsini Machado de Sousa,
A.M. Loyola
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.185927
Subject(s) - keratocystic odontogenic tumor , pathology , ameloblastoma , adenomatoid odontogenic tumor , histogenesis , odontogenic tumor , amelogenesis , immunohistochemistry , medicine , ameloblast , enamel paint , odontogenic , anatomy , dentistry , maxilla
Matrix metalloproteinase-20 (MMP20) (enamelysin) and kallikrein 4 (KLK4) are enzymes secreted by ameloblasts that play an important role in enamel matrix degradation during amelogenesis. However, studies have shown that neoplastic cells can produce such enzymes, which may affect the tumor infiltrative and metastatic behaviors.