Open AccessImmunohistochemical expression of p53 and its clinicopathological correlation with modified Anneroth′s histological grading system
Author(s) -
Kajal V Dave,
Monali Chalishazar,
Vishal R Dave,
Pritam Panja,
Manisha Singh,
Tapan G Modi
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.180922
Subject(s) - grading (engineering) , malignancy , pathology , immunohistochemistry , infiltration (hvac) , clinical significance , medicine , correlation , biology , ecology , physics , geometry , mathematics , thermodynamics
Oral squamous cell carcinoma (OSCC) is an epithelial neoplasm generally beginning as focal overgrowth of altered stem cells near the basement membrane, moving upward and laterally, replacing the normal epithelium. Histopathological grading has been used for many decades in an attempt to predict the clinical behavior of oral squamous cell carcinoma. In the present study, Forty biopsies were studied for histological grading and p53 expression. The p53 expression was studied in relation to clinical parameters such as age, sex of patient and site of tumors. Relation between histological grade of malignancy and p53 protein expression was analysed. All cases were classified according to Anneroth's histological malignancy grading system (1987).