Open AccessEpstein–Barr virus and its association with rheumatoid arthritis and oral lichen planus
Author(s) -
Pooja Adtani,
Malathi Narasimhan
Publication year - 2015
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.174643
Subject(s) - immunology , rheumatoid arthritis , oral lichen planus , medicine , epstein–barr virus , autoimmune hepatitis , genetic predisposition , autoimmune disease , virus , pathogenesis , autoimmune thyroiditis , antibody , thyroiditis , disease , hepatitis
Pathogenesis of autoimmune diseases (AD) is one of a multifactorial milieu. A genetic predisposition, an immune system failure, hormonal imbalance and environmental factors play important roles. Among the many environmental factors, the role of infection is gaining importance in the pathogenesis of various autoimmune disorders; among them, Epstein-Barr virus (EBV) plays a pivotal role. Literature states an association of various AD with EBV namely multiple sclerosis, autoimmune thyroiditis, systemic lupus erythematous, oral lichen planus (OLP), rheumatoid arthritis (RA), autoimmune hepatitis, Sjögren's syndrome and Kawasaki disease; among these, the most commonly occurring are OLP and RA.