Open AccessPerineural invasion in oral squamous cell carcinoma: Case series and review of literature
Author(s) -
BK Varsha,
MB Radhika,
Soumya Makarla,
Moni Abraham Kuriakose,
Gvv Satya Kiran,
G V Padmalatha
Publication year - 2015
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.174630
Subject(s) - basal cell , perineural invasion , dermatology , series (stratigraphy) , medicine , pathology , cancer , biology , paleontology
Oral cancer constitutes 3% of all neoplasms and is the eighth most frequent cancer in the world. Oral squamous cell carcinoma (OSCC) corresponds to 95% of all oral cancers. It is associated with severe morbidity, recurrence and reduced survival rates. Its prognosis is affected by several clinicopathologic factors, one of which is perineural invasion (PNI). It is the third most common form of tumor spread exhibited by neurotropic malignancies that correlate with aggressive behavior, disease recurrence and increased morbidity and mortality. In this retrospective study, our aim was to assess the presence of PNI in different grades of both primary and recurrent cases of OSCC correlating it with tumor size and lymph node status. The various patterns of PNI we encountered were also noted.