Open AccessEstimation of argyrophilic nucleolar organizer regions in different grades of oral submucous fibrosis
Author(s) -
K L Girish,
K L Kumaraswamy,
Usha Balan,
Maji Jose
Publication year - 2015
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.164532
Subject(s) - oral submucous fibrosis , nucleolus organizer region , biology , pathology , medicine , neuroscience , nucleolus , nucleus
Assessment of potential for malignant transformation of oral submucous fibrosis (OSF) through clinical or light microscopic examination of hematoxylin and eosin stained tissue sections is not totally satisfactory. The search is for such a tissue marker that will differentiate those cases of OSF, which carry a higher risk for malignant transformation. During the past few years, numerous workers have validated the usefulness of enumerating argyrophilic nucleolar organizer regions (AgNORs) in predicting the malignant potential of lesions. The present study was carried out to validate the diagnostic potential of this marker.