Open AccessA study of salivary lactate dehydrogenase isoenzyme levels in patients with oral leukoplakia and squamous cell carcinoma by gel electrophoresis method
Author(s) -
Priya Joshi,
Someshwar Golgire
Publication year - 2014
Publication title -
journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.141342
Subject(s) - lactate dehydrogenase , leukoplakia , saliva , pathology , agarose gel electrophoresis , epithelial dysplasia , isozyme , histology , biopsy , medicine , carcinoma , dysplasia , salivary gland , biology , cancer , enzyme , biochemistry , gene
The enzyme lactate dehydrogenase (LDH), which is found in almost all the cells of body tissues, can be separated into five fractions and the isoenzyme pattern is believed to vary according to the metabolic requirement of each tissue. LDH concentration in saliva, as an expression of cellular necrosis, could be considered to be a specific indicator for oral lesions that affect the integrity of the oral mucosa.