Open AccessA phase contrast cytomorphometric study of squames of normal oral mucosa and oral leukoplakia: Original study
Author(s) -
Afreen Nadaf,
Radhika M Bavle,
Lalita J Thambiah,
K Paremala,
M Sudhakara,
M Soumya
Publication year - 2014
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.141339
Subject(s) - oral mucosa , leukoplakia , contrast (vision) , medicine , oral leukoplakia , phase contrast microscopy , dentistry , pathology , optics , physics , cancer
Oral leukoplakia represents the most common potentially malignant oral disorder, representing 85% of such lesions. The worldwide prevalence of leukoplakia is 1.5- 4.3%. Leukoplakia is often associated with carcinogenic exposures, such as from use of tobacco, alcohol or betel nut. The level of risk for malignant transformation of leukoplakia is associated with lesion histology. The overall malignant transformation rates for dysplastic lesions range from 11% to 36%, depending on the length of follow-up. Exfoliative cytology is a simple and minimally invasive method. Phase contrast microscope, an essential tool in the field of biology and medical research provides improved discrimination of cellular details.