Open AccessSecond malignancies in Hodgkin′s disease: A review of the literature and report of a case with a secondary Lennert′s lymphoma
Author(s) -
E. J. G. Norval,
Erich J. Raubenheimer
Publication year - 2014
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.141332
Subject(s) - lymphoma , medicine , radiation therapy , disease , malignancy , chemotherapy , peripheral t cell lymphoma , tonsil , pathology , leukemia , non hodgkin's lymphoma , oncology , t cell , immunology , immune system
A small percentage of patients treated for Hodgkin's disease are at risk of developing a second malignancy. The appearance of secondary malignancies such as leukemia, carcinoma or non-Hodgkin's lymphomas may be attributed to the mutagenic effects of chemotherapy and/or radiotherapy. Most secondary non-Hodgkin's lymphomas are of the B-cell type, but isolated cases were reportedly of a T-cell lineage. A review of the literature pertaining to the development of secondary peripheral T-cell lymphomas is presented along with the description of an additional case. The latter developed in the tonsil and was diagnosed as a Lennert's lymphoma (lymphoepithelioid T cell lymphoma)on histological and immunological grounds. This report also reviews the development of a of peripheral T-cell lymphoma described in patients following chemotherapy and/or radiotherapy for Hodgkin's disease.