Open AccessImmunohistochemical expression of CD34 and basic fibroblast growth factor (bFGF) in oral submucous fibrosis
Author(s) -
Deepak Pandiar,
PM Shameena
Publication year - 2014
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.140718
Subject(s) - vascularity , pathology , basic fibroblast growth factor , oral submucous fibrosis , medicine , precancerous condition , angiogenesis , fibrosis , cd34 , dysplasia , malignant transformation , epithelial dysplasia , malignancy , atrophy , cancer , growth factor , biology , stem cell , receptor , genetics
Oral submucous fibrosis (OSMF) is an insidious chronic fibrotic condition that involves the oral mucosa and occasionally the pharynx and esophagus. Vascularity in OSMF has always been a matter of debate. The prevailing concept is that epithelial atrophy occurs due to lack of perfusion but the recent data challenges this concept. Therefore, the present study was conducted to evaluate the immunoreactivity of CD34 and basic fibroblast growth factor (bFGF) in different histological grades of OSMF. This might further shed light to the role of microvasculature in OSMF, so that the epithelial atrophy and resultant malignant transformation seen in the advanced stages might be elucidated.