Open AccessOral lesions associated with Nevirapine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A report of 10 cases
Author(s) -
R. N. Raviteja Reddy,
PChandra Shekar,
KLalith Prakash Chandra,
RS Aravind
Publication year - 2013
Publication title -
journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.125214
Subject(s) - toxic epidermal necrolysis , nevirapine , mucocutaneous zone , dermatology , medicine , human immunodeficiency virus (hiv) , sex organ , immunology , pathology , biology , disease , antiretroviral therapy , viral load , genetics
Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are closely related severe, acute mucocutaneous reactions usually caused by drugs. They are acute life-threatening conditions and cause widespread necrosis of the epithelium. There is persistence of a high risk of SJS or TEN in relation to human immunodeficiency virus (HIV) infection associated with exposure to nevirapine (NVP). In this article, we present nine cases of SJS and one case of TEN in HIV-seropositive individuals who developed cutaneous, oral, ocular and genital lesions while being treated with NVP.