Open AccessVEGF and CD 34: A correlation between tumor angiogenesis and microvessel density-an immunohistochemical study
Author(s) -
Ipsita Kukreja,
Prakhar Kapoor,
Revati Deshmukh,
Venkatesh Kulkarni
Publication year - 2013
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.125200
Subject(s) - angiogenesis , immunohistochemistry , pathology , microvessel , neovascularization , medicine , h&e stain , cd31 , vascular endothelial growth factor , cancer research , vegf receptors
Angiogenesis is the formation of new vessels from preexisting ones which takes place by capillary sprouting. It is seen in healing, at sites of injury and collateral circulation in ischemia. It is also seen in tumors, as once the original blood supply of a tumor is exhausted it cannot grow without further blood supply. Also as the angiogenic capacity of a tumor increases, its microvasculature, that is, microvessel density (MVD) also increases. Based on this literary evidence we carried out an immunohistochemical (IHC) study to observe the relationship between the expression of vascular endothelial growth factor (VEGF) [angiogenesis] and CD 34 [MVD] in oral squamous cell carcinoma (OSCC).