Open AccessStromal myofibroblasts in nonmetastatic and metastatic oral squamous cell carcinoma: An immunohistochemical study
Author(s) -
Sudheendra Udyavara Sridhara,
Nidhi Choudaha,
Sowmya Kasetty,
Prathamesh Satish Joshi,
Shreenivas Kallianpur,
Manisha Tijare
Publication year - 2013
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.119758
Subject(s) - cd34 , stromal cell , pathology , immunohistochemistry , metastasis , myofibroblast , stroma , medicine , cancer associated fibroblasts , biology , cancer , fibrosis , stem cell , genetics
Myofibroblasts are one of the important components of the tumor microenvironment which could possibly play an important role in tumor progression. The purpose of this study was to compare the presence of α-smooth muscle actin (α-SMA) and CD34 positive fibroblasts in nonmetastatic and metastatic oral squamous cell carcinoma and to evaluate their role in tumor metastasis.