Open AccessFluorescence in-situ hybridization technique as a diagnostic and prognostic tool in oral squamous cell carcinoma
Author(s) -
Sunil Pm,
CR Ramachandran,
Gokul Sridharan,
N Jaisanghar
Publication year - 2013
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.110731
Subject(s) - fluorescence in situ hybridization , biology , in situ hybridisation , chromosome , cytogenetics , fish <actinopterygii> , basal cell , pathology , in situ hybridization , gene , medicine , genetics , gene expression , fishery
Early diagnosis and appropriate management are of prime importance for oral squamous cell carcinoma (OSCC) in the present scenario. Molecular changes in OSCC are well documented with the occurrence of a wide range of genetic damage. Identification of the genetic damage in OSCC using various diagnostic aids is mandatory, and one of the important advances in this field is cytogenetics using fluorescence in-situ hybridization (FISH). The aim of the present study is to analyze the genetic alteration in OSCC using FISH as a diagnostic aid.