Open AccessGut barrier function and systemic endotoxemia after laparotomy or laparoscopic resection for colon cancer: A prospective randomized study
Author(s) -
M Schietroma,
Beatrice Pessia,
F Carlei,
Emanuela Marina Cecilia,
Gianfranco Amicucci
Publication year - 2016
Publication title -
journal of minimal access surgery
Language(s) - English
Resource type - Journals
eISSN - 0972-9941
pISSN - 1998-3921
DOI - 10.4103/0972-9941.169982
Subject(s) - medicine , laparotomy , laparoscopic surgery , colorectal cancer , surgical stress , surgery , prospective cohort study , colectomy , laparoscopy , randomized controlled trial , systemic inflammatory response syndrome , gastroenterology , anesthesia , cancer , sepsis
The gut barrier is altered in certain pathologic conditions (shock, trauma, or surgical stress), resulting in bacterial and/or endotoxin translocation from the gut lumen into the systemic circulation. In this prospective randomized study, we investigated the effect of surgery on intestinal permeability (IP) and endotoxemia in patients undergoing elective colectomy for colon cancer by comparing the laparoscopic with the open approach.