Open AccessStudy of the in vitro and in vivo antileishmanial activities of nimodipine in susceptible BALB/c mice
Author(s) -
Reza Azadi,
Ghazal Alipour-Talesh,
Mohammad Javad Yazdanpanah,
Seyedeh Hoda Alavizadeh,
Masoud Maleki,
Mahnaz Banihashemi,
Mahmoud Reza Jaafari
Publication year - 2020
Publication title -
journal of vector borne diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.581
H-Index - 41
ISSN - 0972-9062
DOI - 10.4103/0972-9062.308805
Subject(s) - nimodipine , meglumine antimoniate , pharmacology , amphotericin b , in vivo , amastigote , medicine , chemistry , leishmania , cutaneous leishmaniasis , leishmaniasis , calcium , immunology , biology , antifungal , microbiology and biotechnology , parasite hosting , dermatology , world wide web , computer science
Pentavalent antimonials are the standard treatment for cutaneous leishmaniasis (CL), however, treatment failures are frequent. Nimodipine, a calcium channel blocker is known to show promising antiprotozoal effects. Here, we investigated the antileishmanial effect of Nimodipine in both in vitro and in vivo BALB/c mice model of CL. We also compared the in vivo effect with amphotericin B and meglumine antimoniate in the experimental CL mice model.