Open AccessRole of IL-17 gene polymorphism in Indian kala-azar
Author(s) -
R Khatonier,
Abdul Mabood Khan,
Pallab Sarmah,
Giasuddin Ahmed
Publication year - 2020
Publication title -
journal of vector borne diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.581
H-Index - 41
ISSN - 0972-9062
DOI - 10.4103/0972-9062.308795
Subject(s) - visceral leishmaniasis , genotype , leishmania donovani , allele , immunology , restriction fragment length polymorphism , biology , leishmaniasis , medicine , polymerase chain reaction , logistic regression , gastroenterology , genetics , gene
Visceral leishmaniasis or kala-azar is a fatal protozoan disease caused by an obligate intracellular parasite, Leishmania donovani. Susceptibility, establishment of infection and severity of this disease depend upon many factors, but it is the host immune system that plays decisive role in disease progression. Keeping this view into consideration, we investigated the probable relationship between polymorphisms rs2275913 and rs8193036 in IL-17 gene, and its association as a risk factor for kala-azar in an endemic population of Assam, India.