Open AccessSpecies-specific and cross-reactive antigen of filarial worm: Brugia malayi and Setaria digitata
Author(s) -
Alok Satapathy,
Prakash Kumar Sahoo
Publication year - 2019
Publication title -
journal of vector borne diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.581
H-Index - 41
ISSN - 0972-9062
DOI - 10.4103/0972-9062.302035
Subject(s) - brugia malayi , biology , wuchereria bancrofti , antigen , filariasis , microfilaria , virology , lymphatic filariasis , immunology , antibody , helminthiasis , parasite hosting , helminths , world wide web , computer science
Generally filarial antigens have been found to be cross-reactive in nature. Identification of genus and species-specific antigens has not been successful so far. Due to lack of human adult filarial parasite, researchers have been using other adult worms like Setaria digitata, a cattle parasite or Brugia malayi, a rodent model for their research work. In this situation, specificity of the prepared antigen (S. digitata or B. malayi) to detect the antibodies to Wuchereria bancrofti is questionable.