Open AccessSynthesis of novel amodiaquine analogs and evaluation of their in vitro and in vivo antimalarial activities
Author(s) -
Azar Tahghighi,
Arezoo Rafie Parhizgar,
Safoura Karimi,
Mahboubeh Irani
Publication year - 2019
Publication title -
journal of vector borne diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.581
H-Index - 41
ISSN - 0972-9062
DOI - 10.4103/0972-9062.289395
Subject(s) - amodiaquine , in vivo , in vitro , pharmacology , chemistry , traditional medicine , biology , medicine , chloroquine , malaria , biochemistry , microbiology and biotechnology , immunology
Due to the rapid increase of drug resistance in Plasmodium parasites, there is a pressing need of developing new antiplasmodial drugs. In this study, new amodiaquine (AQ) analogs were synthesized, followed by an evaluation of their antiplasmodial activity.