Open AccessIsovaleric acid and avicequinone-C are Chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa
Author(s) -
O P Brinda,
Deepu Mathew,
Shylaja,
Peg Davis,
K. Anita Cherian,
P. A. Valsala
Publication year - 2019
Publication title -
journal of vector borne diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.581
H-Index - 41
ISSN - 0972-9062
DOI - 10.4103/0972-9062.263719
Subject(s) - adme , chikungunya , chemistry , virus , traditional medicine , docking (animal) , drug , antiviral drug , pharmacology , biology , virology , medicine , veterinary medicine
Oral administration of tender leaf extract of Glycosmis pentaphylla is traditionally known to prevent the chikungunya virus infection. Even with wide usage, the antiviral components in this plant are neither identified nor characterized. This study was carried out with the objectives of profiling the phytocompounds in this plant through LC-MS/MS and to identify the active antiviral constituents and their drug-likeliness through molecular docking.