Open AccessGenetic diversity and structural analysis of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE) from Plasmodium falciparum
Author(s) -
Kavita Kadian,
Sonam Vijay,
Ritu Rawal,
Jagbir Singh,
Anup Anvikar,
Veena Pande,
Arun Dev Sharma
Publication year - 2018
Publication title -
journal of vector borne diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.581
H-Index - 41
ISSN - 0972-9062
DOI - 10.4103/0972-9062.256562
Subject(s) - plasmodium falciparum , biology , gene , genetic diversity , genetics , malaria , phylogenetic tree , computational biology , population , immunology , medicine , environmental health
Plasmodium parasite harbours unique methylerythritol phosphate (MEP) pathway which is obligatory for the biosynthesis of isoprenoids. In malaria parasites, the isoprenoids are indispensable during hepatic, erythrocytic and gametocytic stages. Owing to the criticality of MEP pathway and the potential of its enzymes to act as antimalarial drug target, this study comprehensively investigated the genetic diversity and structural composition of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE), fourth enzyme of MEP pathway in Indian Plasmodium falciparum (PfIspE).