Open AccessTolerability and efficacy of paliperidone ER compared to olanzapine in the treatment of schizophrenia: A randomized, double-blind, multicentric trial
Author(s) -
Sandip Shah,
D Joshi
Publication year - 2011
Publication title -
industrial psychiatry journal/industrial psychiatry journal
Language(s) - English
Resource type - Journals
eISSN - 0976-2795
pISSN - 0972-6748
DOI - 10.4103/0972-6748.98411
Subject(s) - paliperidone , olanzapine , akathisia , positive and negative syndrome scale , clinical global impression , risperidone , tolerability , adverse effect , medicine , randomized controlled trial , schizophrenia (object oriented programming) , extrapyramidal symptoms , psychology , psychiatry , antipsychotic , psychosis , alternative medicine , pathology , placebo
Paliperidone is an active metabolite of risperidone and actss through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.