Open AccessUse of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome
Author(s) -
Prashant Nasa,
Deepak Sehrawat,
Sudha Kansal,
Rajesh Chawla
Publication year - 2010
Publication title -
indian journal of critical care medicine/indian journal of critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 30
eISSN - 1998-359X
pISSN - 0972-5229
DOI - 10.4103/0972-5229.74174
Subject(s) - medicine , septic shock , toxic shock syndrome , sepsis , shock (circulatory) , staphylococcus aureus , systemic inflammatory response syndrome , exotoxin , intensive care medicine , immunology , microbiology and biotechnology , bacteria , toxin , genetics , biology
Toxic shock syndrome (TSS) is a serious, potentially life-threatening condition resulting from an overwhelming immunological response to an exotoxin released by Staphylococcus aureus and group A streptococci. High index of suspicion, early diagnosis and aggressive therapeutic measures must be instituted in view of high mortality of the TSS. In recent years, new agents have been tested to reduce morbidity and mortality in patients with severe sepsis, in addition to standard supportive measures. Among them, recombinant human activated protein C (rhAPC) has been reported to significantly reduce mortality and morbidity in patients with severe sepsis and two or more acute organ failures. We describe our experience with this drug in the early reversal of septic shock from TSS.