Safety and efficacy of polymyxin B in multidrug resistant gram-negative severe sepsis and septic shock | Zendy

Arghya Majumdar | Zendy; Purnendu Sekhar Das | Zendy

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Safety and efficacy of polymyxin B in multidrug resistant gram-negative severe sepsis and septic shock

Author(s) -

Arghya Majumdar,

Purnendu Sekhar Das

Publication year - 2008

Publication title -

indian journal of critical care medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.317

H-Index - 30

eISSN - 1998-359X

pISSN - 0972-5229

DOI - 10.4103/0972-5229.45074

Subject(s) - medicine , polymyxin , septic shock , polymyxin b , sepsis , colistin , nephrotoxicity , intensive care medicine , intensive care , antibiotics , microbiology and biotechnology , kidney , biology

The emergence of multidrug resistant strains of Gram-negative bacteria, especially the lactose nonfermenters like Pseudomonas and Acinetobacter, in the intensive care units have prompted renewed worldwide interest in the polymyxins. However, perceived nephrotoxicity has been a major vexation limiting their early and regular use in severe sepsis. This study was conducted to assess the safety and efficacy of polymyxin B in patients with severe sepsis and septic shock.

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