Open AccessSafety and efficacy of polymyxin B in multidrug resistant gram-negative severe sepsis and septic shock
Author(s) -
Ayanava Majumdar,
Purnendu Sekhar Das
Publication year - 2008
Publication title -
indian journal of critical care medicine/indian journal of critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 30
eISSN - 1998-359X
pISSN - 0972-5229
DOI - 10.4103/0972-5229.45074
Subject(s) - medicine , polymyxin , septic shock , polymyxin b , sepsis , colistin , nephrotoxicity , intensive care medicine , intensive care , antibiotics , microbiology and biotechnology , kidney , biology
The emergence of multidrug resistant strains of Gram-negative bacteria, especially the lactose nonfermenters like Pseudomonas and Acinetobacter, in the intensive care units have prompted renewed worldwide interest in the polymyxins. However, perceived nephrotoxicity has been a major vexation limiting their early and regular use in severe sepsis. This study was conducted to assess the safety and efficacy of polymyxin B in patients with severe sepsis and septic shock.