Open AccessUse of yttrium-90 hydroxyapatite radiosynovectomy as a primary modality of treatment in diffuse pigmented villonodular synovitis of the knee joint: A first case report
Author(s) -
Koramadai Karuppusamy Kamaleshwaran,
David V. Rajan,
Boopathi Krishnan,
Thirumalaisamy Subbaih Gounder,
Sudipta Chakraborty,
Radhakrishnan Kalarickal,
Vyshakh Mohanan,
Ajit Shinto
Publication year - 2015
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/0972-3919.147539
Subject(s) - pigmented villonodular synovitis , medicine , synovectomy , knee joint , synovitis , treatment modality , radiology , yttrium , hemarthrosis , surgery , nuclear medicine , arthritis , rheumatoid arthritis , chemistry , organic chemistry , oxide
Pigmented villonodular synovitis (PVNS) is a rare, relatively benign, intra-articular lesion characterized by a slowly progressive proliferation of synovial tissue. Knee is the most frequently involved joint. Localized and diffuse forms of synovial involvement were reported. In extensive diffuse cases, total synovectomy is needed, almost impossible to achieve. Hence, other treatment modalities such as intra-articular injection of yttrium-90 have been tried and shown to be effective in reducing the rate of local recurrence with "acceptable" joint damage. Radiosynovectomy is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. We describe the first case report of use of yttrium-90 hydroxyapatite particulates in a 33-year-old male who presented with diffuse PVNS of knee joint as a primary modality of treatment.