Open AccessPoor fluorodeoxyglucose uptake in myocardial viability study in nondiabetic Friedreich′s ataxia patient
Author(s) -
Sushanti Patil,
Vikram Lele
Publication year - 2014
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/0972-3919.142638
Subject(s) - medicine , ataxia , fluorodeoxyglucose , ejection fraction , cardiology , diabetes mellitus , frataxin , basal (medicine) , positron emission tomography , nuclear medicine , endocrinology , heart failure , insulin , psychiatry , iron binding proteins , transferrin
A 48-year-old man, a known case of Friedreich's ataxia (FRDA) underwent cardiac fluorodeoxyglucose (FDG) positron emission tomography -computed tomography (PET/CT) for evaluation of myocardial viability. Tetrofosmin images showed an enlarged left ventricular cavity with small mid and basal inferior and apical infarct global hypokinesia with ejection fraction of 39%. Fluorodeoxyglucose images showed poor quality myocardial images. Friedreich's ataxia is associated with a high incidence of diabetes mellitus. Non-diabetic patients with Friedreich's ataxia have insulin resistance. This is associated with a reduction in the affinity of insulin receptors and membrane abnormality that alters the binding function of the insulin receptor.