Open AccessRole of vitamin B 12 , folate, and thyroid stimulating hormone in dementia: A hospital-based study in north Indian population
Author(s) -
Rachna Agarwal,
Neelam Chhillar,
Suman Kushwaha,
Neeraj Singh,
Chandra Bhushan Tripathi
Publication year - 2010
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.74193
Subject(s) - medicine , dementia , vitamin b12 , homocysteine , hormone , b vitamins , population , vitamin d and neurology , endocrinology , physiology , gastroenterology , disease , environmental health
Vitamin B(12) and folate represent modifiable risk factors for dementia. They may increase the risk of Alzheimer's dementia (AD) and vascular dementia (VaD) as their deficiency can increase the homocysteine level due to slowed methylation reaction. Homocysteine has a neurotoxic effect that could lead to neurologic disturbances. Hence, it is important to explore the status of serum B(12) and folate in AD and VaD to evolve the treatment strategies for the same.