Open AccessTransforming growth factor-β1 (C509T, G800A, and T869C) gene polymorphisms and risk of ischemic stroke in North Indian population: A hospital-based case-control study
Author(s) -
Pradeep Kumar,
Shubham Misra,
Amit Kumar,
Faruq Mohammad,
Sunil Shakya,
Gyan Vardhan,
Vivekanandhan Subbiah,
Achal Kumar Srivastava,
Kameshwar Prasad
Publication year - 2017
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.199910
Subject(s) - medicine , dyslipidemia , odds ratio , haplotype , logistic regression , case control study , stroke (engine) , diabetes mellitus , family history , risk factor , genotype , obesity , endocrinology , genetics , gene , biology , mechanical engineering , engineering
Transforming growth factor-beta 1 (TGF-β1) is a multifunctional pleiotropic cytokine involved in inflammation and pathogenesis of cerebrovascular diseases. There is limited information on the association between variations within the TGF-β1 gene polymorphisms and risk of ischemic stroke (IS). The aim of this study was to investigate the association of the TGF-β1 gene (C509T, G800A, and T869C) polymorphisms, and their haplotypes with the risk of IS in North Indian population.