Open AccessHomogeneity and the outcome of clinical trials: An appraisal of the outcome of recent clinical trials on endovascular intervention in acute ischemic stroke
Author(s) -
Shakir Husain,
PR Srijithesh
Publication year - 2016
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.173308
Subject(s) - medicine , clinical trial , psychological intervention , stroke (engine) , acute stroke , outcome (game theory) , context (archaeology) , intensive care medicine , population , randomized controlled trial , physical therapy , surgery , psychiatry , mechanical engineering , paleontology , environmental health , tissue plasminogen activator , engineering , biology , mathematics , mathematical economics
Clinical trials that allow significant heterogeneity of population or interventions often result in uncertain outcomes. In this paper, we review the outcomes of five recent trials of endovascular interventions in acute ischemic stroke in the context of the neutral results of previous large clinical trials on the subject.