Open AccessReversible cerebral and brain stem dysfunction in n: Hexane neuropathy
Author(s) -
Vinita Puri,
Abhishek Gupta,
Neera Chaudhry,
Ravindra Kumar Saran
Publication year - 2015
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.160088
Subject(s) - medicine , dysarthria , corneal reflex , nystagmus , polyneuropathy , ataxia , audiology , cerebellar ataxia , anesthesia , anatomy , reflex , surgery , psychiatry
A 18-year-old male, screen printer by profession developed sensory motor polyneuropathy, change in his behavior, bilateral 6(th) and 7(th) cranial nerve palsies, down beat nystagmus and cerebellar dysarthria. He had bilaterally prolonged P100 latency; left: 137 ms; right: 144 ms. P 37 was not recordable on either side while N 20 was normal. The inter latency difference between Ipsilateral R2 and Contralateral R2 was 6.15 ms, on the left side and normal on the right side. In the follow-up, there was normalization of the blink reflex study, improvement in P100 latency [left: 114 ms; right: 120 ms.] but worsening of peripheral nerve conductions. The sequential clinical recovery was of the behavioral dysfunction, down beat nystagmus, 6(th) nerve, 7(th) nerve involvement and ataxia, in that order. Sural nerve biopsy showed loss of large diameter myelinated fibers.