Open AccessEffect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer′s disease
Author(s) -
Rachna Agarwal,
Puneet Talwar,
Suman Kushwaha,
Chandra Bhushan Tripathi,
Ritushree Kukreti
Publication year - 2015
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.157255
Subject(s) - leptin , medicine , endocrinology , apolipoprotein e , allele , apolipoprotein b , cholesterol , genotype , lipoprotein , alzheimer's disease , biology , obesity , disease , genetics , gene
Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E ε4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele.