Open AccessSpinocerebellar ataxia-10 with paranoid schizophrenia
Author(s) -
Bhavesh Trikamji,
Parampreet Singh,
Shrikant Mishra
Publication year - 2014
Publication title -
annals of indian academy of neurology (print)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.144285
Subject(s) - dysmetria , ataxia , medicine , psychosis , hyperreflexia , schizophrenia (object oriented programming) , cerebellar ataxia , paranoid schizophrenia , ataxic gait , audiology , psychiatry , psychology , spinocerebellar ataxia , neurological examination , cerebellum , pediatrics , neuroscience
Spino-cerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that is characterized by cerebellar ataxia, seizures and nystagmus with a fragmented pursuit. Schizophrenia has been reported with SCAs 1 and 2 yet in SCA 10, psychiatric manifestations are uncommon. We report a Hispanic family involving a father and his four children with SCA10 genetic mutation. Two of his children, a 20-year-old female and a 23-year-old male, presented with gradually progressive spino-cerebellar ataxia and paranoid schizophrenia. Neurological examination revealed ocular dysmetria, dysdiadokinesia, impaired finger-to-nose exam, gait ataxia and hyperreflexia in both the cases. Additionally, they had a history of psychosis with destructive behavior, depression and paranoid delusions with auditory hallucinations. Serology and CSF studies were unremarkable and MRI brain revealed cerebellar volume loss. Ultimately, a test for ATAXIN-10 mutation was positive thus confirming the diagnosis of SCA10 in father and his four children. We now endeavor to investigate the association between schizophrenia and SCA10.