Open AccessSpectroscopic correlation and role of Azathioprine in long-term remission in patients of Hashimoto encephalopathy
Author(s) -
Harpreet Singh,
Sucharita Ray,
Shalini Agarwal,
Raj Pal Verma,
Paulomi Talapatra,
Latika Gupta
Publication year - 2013
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.116936
Subject(s) - azathioprine , medicine , immunosuppression , encephalopathy , gastroenterology , radiological weapon , surgery , disease
Hashimoto encephalopathy remains a Rubik's cube for the present generation of clinical research. Myriad presentations have been noted, and observations recorded in few subgroups of patients have gone on only to be trashed by a second group of patients with a completely different clinical profile. Steroids have been traditionally held to be the treatment for this condition, but long-term side effects associated with it limits its use. Although multiple drugs have been tried, yet there exists no data for their long-term efficacy in maintaining remission. No radiological findings have been consistently associated with this condition. We report the use of azathioprine in maintaining long-term remission in one such patient with Hashimoto encephalopathy and the presence of lactate peak in magnetic resonance spectroscopy of the patient, which showed dramatic regression with institution of immunosuppression.