Open AccessActinic cheilitis with a familial pattern: An unusual case
Author(s) -
Surekha Murthi,
Shilpa Ravishankar Thayi,
Usha Konidala,
Vani Chappidi
Publication year - 2014
Publication title -
journal of indian academy of oral medicine and radiology
Language(s) - English
Resource type - Journals
eISSN - 0975-1572
pISSN - 0972-1363
DOI - 10.4103/0972-1363.141875
Subject(s) - medicine , dermatology , lower lip , malignancy , genetic predisposition , malignant transformation , basal cell , pathology , surgery , disease
Actinic cheilitis is a chronic inflammatory disorder of the lip, affecting the lower lip mainly, caused by cumulative long-term effects of ultraviolet (UV) radiation in sunlight. It is a premalignant condition with a malignancy potential of 6-10%. It is reported that it almost exclusively occurs in fair-skinned people and those who work outdoors. However, it has recently been reported that actinic cheilitis is not exclusive to fair-skinned people. It is most common in middle-aged or older male patients. Diagnosis of actinic cheilitis is mainly based on demographical, clinical, and histopathological findings. Factors such as socioeconomic status, smoking, dietary habits, and genetic predisposition are also associated with lip cancer. Here, we present a case of actinic cheilitis in two siblings and in their mother, showing a familial pattern. An incisional biopsy of the lower lip in the mother showed severe dysplastic changes indicating transformation to squamous cell carcinoma