Open AccessAssociation between interleukin-1 gene polymorphism and severity of chronic periodontitis in a south Indian population group
Author(s) -
Patil Archana,
Arif Salman,
Tamil Selvan Kumar,
P. Saraswathi,
K H Panishankar,
P. Kumarasamy
Publication year - 2012
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.99258
Subject(s) - medicine , genotype , chronic periodontitis , gastroenterology , periodontitis , gene polymorphism , interleukin , immunology , gene , biology , genetics , cytokine
Periodontitis is a bacterial disease modified by multiple factors. Interleukin-1 (IL-1) is a key regulator of the host response and a major modulator of extracellular matrix catabolism and bone resorption. It has been reported that variations in IL-1 gene are associated with increased susceptibility to periodontitis. The aims of the study were 1) to analyze the distribution of single nucleotide polymorphism of IL-1 (IL-1A-+4845 and IL-1B-+3954) and 2) to correlate the association of the composite genotype with the severity of chronic periodontitis.