Open AccessClinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients
Author(s) -
Swati Agarwal,
Krishna Kumar Chaubey,
Abhinav Chaubey,
Vikas Agarwal,
Ellora Madan,
Manvi Chandra Agarwal
Publication year - 2016
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.194270
Subject(s) - simvastatin , medicine , scaling and root planing , chronic periodontitis , dentistry , periodontitis , gingival and periodontal pocket , placebo , drug , pharmacology , pathology , alternative medicine
Simvastatin (SMV), a new locally delivered drug of class statins, is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Statins, besides having lipid-lowering abilities, also have pleiotropic effects like host modulation and bone regeneration. The present study was designed to investigate the effectiveness of SMV, 1.2 mg, in an indigenously prepared biodegradable controlled-release gel as an adjunct to scaling and root planing (SRP).