Evaluation of mRNA expression of the transcription factors of Th1 and Th2 subsets (T-bet and GATA-3) in periodontal health and disease - A pilot study in south Indian population | Zendy

Nichenametla Rajesh | Zendy; Kurumathur Vasudevan Arun | Zendy; Tirumelveli Saravanan Subbu Kumar | Zendy; Kondareddy Krishna Mohan Reddy | Zendy; Swarna Alamelu | Zendy; Bhimavarapu Ravinder Reddy | Zendy

Open Access

Evaluation of mRNA expression of the transcription factors of Th1 and Th2 subsets (T-bet and GATA-3) in periodontal health and disease - A pilot study in south Indian population

Author(s) -

Nichenametla Rajesh,

Kurumathur Vasudevan Arun,

Tirumelveli Saravanan Subbu Kumar,

Kondareddy Krishna Mohan Reddy,

Swarna Alamelu,

Bhimavarapu Ravinder Reddy

Publication year - 2015

Publication title -

journal of indian society of periodontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 28

eISSN - 0975-1580

pISSN - 0972-124X

DOI - 10.4103/0972-124x.164748

Subject(s) - medicine , reverse transcriptase , reverse transcription polymerase chain reaction , periodontitis , immunology , messenger rna , population , disease , transcription factor , real time polymerase chain reaction , biopsy , andrology , pathology , polymerase chain reaction , gene , biology , genetics , environmental health

Based on their respective pro- or anti-inflammatory cytokine profiles, the Th1/Th2 paradigm explains pathogenic mechanisms involved in periodontal disease. Establishment of Th1 and Th2 subsets from a naive T-cell precursor depends on transcriptional regulation. The aim of this study was to compare the expression of master transcription factor regulators T-bet and GATA-3, respectively, to indicate the predominance of Th1 and Th2 subsets in the presence and absence of periodontal disease.

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