Open AccessEvaluation of mRNA expression of the transcription factors of Th1 and Th2 subsets (T-bet and GATA-3) in periodontal health and disease - A pilot study in south Indian population
Author(s) -
Rajesh Nichenametla,
KV Arun,
Tamil Selvan Kumar,
Kondareddy Krishna Mohan Reddy,
Swarna Alamelu,
Bhimavarapu Ravinder Reddy
Publication year - 2015
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.164748
Subject(s) - medicine , reverse transcriptase , reverse transcription polymerase chain reaction , periodontitis , immunology , messenger rna , population , disease , transcription factor , real time polymerase chain reaction , biopsy , andrology , pathology , polymerase chain reaction , gene , biology , genetics , environmental health
Based on their respective pro- or anti-inflammatory cytokine profiles, the Th1/Th2 paradigm explains pathogenic mechanisms involved in periodontal disease. Establishment of Th1 and Th2 subsets from a naive T-cell precursor depends on transcriptional regulation. The aim of this study was to compare the expression of master transcription factor regulators T-bet and GATA-3, respectively, to indicate the predominance of Th1 and Th2 subsets in the presence and absence of periodontal disease.