Open AccessEvaluation of the effect of nicotine and metabolites on the periodontal status and the mRNA expression of interleukin-1β in smokers with chronic periodontitis
Author(s) -
Ajita Meenawat,
Vivek Govila,
Sudhir K. Goel,
Sunil Verma,
Karan Punn,
Vivek Srivastava,
Rameshwar Shantaram Dolas
Publication year - 2015
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.157879
Subject(s) - medicine , chronic periodontitis , periodontitis , pathogenesis , nicotine , immune system , cytokine , interleukin , immunology , dentistry
Smoking is an important environmental risk factor involved in the causation and progression of periodontal disease. Smoking can impair various components of the host immune response and immune system. The virulence factors of periodontal pathogens stimulate inflammatory cytokine expression by mononuclear cells. IL-1β is the key mediator involved in the pathogenesis and disease progression. Therefore, whole gingival biopsy samples are assessed for this increased expression of IL-1.