Interleukin-11 - its role in the vicious cycle of inflammation, periodontitis and diabetes: A clinicobiochemical cross-sectional study | Zendy

Lakshmi Puzhankara | Zendy; R. Satya Prasad | Zendy; A Suchetha | Zendy; MundinamaneBasawalingappa Darshan | Zendy; SM Apoorva | Zendy; GulabdasBharwani Ashit | Zendy

Open Access

Interleukin-11 - its role in the vicious cycle of inflammation, periodontitis and diabetes: A clinicobiochemical cross-sectional study

Author(s) -

Lakshmi Puzhankara,

R. Satya Prasad,

A Suchetha,

MundinamaneBasawalingappa Darshan,

SM Apoorva,

GulabdasBharwani Ashit

Publication year - 2015

Publication title -

journal of indian society of periodontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 28

eISSN - 0975-1580

pISSN - 0972-124X

DOI - 10.4103/0972-124x.152108

Subject(s) - proinflammatory cytokine , medicine , periodontitis , diabetes mellitus , glycated hemoglobin , interleukin , inflammation , glycemic , chronic periodontitis , cytokine , type 2 diabetes , immunology , gastroenterology , endocrinology

Interleukin-11 (IL-11) is a multifunctional cytokine with a probable regulatory role in the inflamed periodontal tissue. It has also been shown to inhibit the production of potent proinflammatory cytokines like tumor necrosis factor-alpha, IL-6 and IL-1β in vitro. Type 2 diabetes mellitus, which demonstrates an increase in proinflammatory cytokines, might hypothetically, display a decrease in the levels of IL-11, which down-regulates synthesis of the proinflammatory cytokines.

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