Open AccessInterleukin-11 - its role in the vicious cycle of inflammation, periodontitis and diabetes: A clinicobiochemical cross-sectional study
Author(s) -
Rohit Prasad,
A Suchetha,
Lakshmi Puzhankara,
Mundinamane Basawalingappa Darshan,
S M Apoorva,
Gulabdas Bharwani Ashit
Publication year - 2015
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.152108
Subject(s) - proinflammatory cytokine , medicine , periodontitis , diabetes mellitus , glycated hemoglobin , interleukin , inflammation , glycemic , chronic periodontitis , cytokine , type 2 diabetes , immunology , gastroenterology , endocrinology
Interleukin-11 (IL-11) is a multifunctional cytokine with a probable regulatory role in the inflamed periodontal tissue. It has also been shown to inhibit the production of potent proinflammatory cytokines like tumor necrosis factor-alpha, IL-6 and IL-1β in vitro. Type 2 diabetes mellitus, which demonstrates an increase in proinflammatory cytokines, might hypothetically, display a decrease in the levels of IL-11, which down-regulates synthesis of the proinflammatory cytokines.